A mildly inducible and selective cross-link methodology for RNA duplexes.
نویسندگان
چکیده
We here report on the furan oxidation methodology for interstrand cross-linking of RNA duplexes, which have a different structure and are more stiff, reactive and labile than their DNA counterparts. Through this mildly inducible approach, natural unmodified RNA can be selectively cross-linked in high yield. The method therefore has direct applications in the increasing number of RNA based technologies.
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ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 12 6 شماره
صفحات -
تاریخ انتشار 2014